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Clinicians should counsel patients that full therapeutic effects on HbA1c and weight may not be apparent until 12 to 16 weeks after initiation

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The sustained nature of the GLP-1 increase suggests the possibility that metformin may in part provide cardio-metabolic benefit, even in a non-diabetic population and beyond reducing the risk of developing T2DM, by increasing exposure of treated individuals to GLP-1 in the longer term

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(Smoking is a risk factor for macular degeneration and blue-light exposure is a contentious one .) This study also did not differentiate between GLP-1 receptor agonists, like semaglutide vs

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