Which comes first: Chicken or egg
It is a tripeptide, composed of three amino acids: glutamate (glutamic acid), cysteine and glycine
The methylation enzymes (BHMT, MAT) begin upregulating, but tissue SAMe levels aren't yet optimised
This can result from chronic oxidative stress, heavy metal toxicity (especially iron overload), persistent infections, nutrient insufficiencies (sulfur amino acids, glycine, glutamate, selenium, B-vitamins), liver dysfunction, metabolic stress, and genetic polymorphisms in key enzymes like glutamate-cysteine ligase (GCL) or glutathione S-transferases (GSTs)
A perhaps surprising appearance in the top five focus areas was Prader-Willi syndrome, which is the focus of 56 studies