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There is also concern about medication adherence in a population that may struggle with consistent self-care behaviours

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The molar excess of BCPB in relation to N-Hcy-Lys was 50:1

Age 65 or Greater: The risk of metformin-associated lactic acidosis increases with the patient's age because elderly patients have a greater likelihood of having hepatic, renal, or cardiac impairment than younger patients