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Detailed Category Analysis# Receptor Targets# Retatrutide : Triple agonist: GIP, GLP-1, and glucagon receptors simultaneously Tirzepatide : Dual agonist: GIP and GLP-1 receptors Advantage : Retatrutide Weight Loss Efficacy# Retatrutide : Up to 28.7% body weight reduction at 68 weeks (Phase 3 TRIUMPH-4)

The Web of Science search strategy was: AB=(children OR pediatric) AND AB=(growth hormone OR growth hormone deficiency OR growth hormone treatment OR recombinant growth hormone) AND AB=(sleep quality OR sleep pattern OR sleep duration OR sleep efficiency OR sleep satisfaction OR sleep health) AND AB=(sleep study OR questionnaires OR polysomnography) NOT AB=(syndrome) NOT AB=(review OR case report)

doi: 10.1016/j.jemrpt.2025.100139 14 SoodNBansalOGargRHoskoteA

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