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Naringin, like other polyphenols, undergo extensive metabolism in the gut, thereby enhancing the growth of beneficial bacteria such as Bifidobacteria and Lactobacillus [172]

Notably, the lower weight loss (-13.7%) observed in REDEFINE 2 among individuals with T2D suggests that the magnitude of benefit achieved with combined GLP-1 and amylin receptor agonism may depend on the underlying metabolic status, highlighting the need for a more nuanced understanding of the mechanisms governing treatment response [13]

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