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doi: 10.1126/science.1092385 19 JanoffA

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To determine which proteoforms may be associated with pathological and cognitive diagnosis on a continuous scale, avoiding subjective between-class limits, parallel linear models were fit with quantification ratio of each peptide as outcome variables, and global cognition Z-score, global pathology Z-score, age at death, sex, post-mortem interval (hours) and number of years in education as explanatory variables

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A clinician evaluates your baseline health, identifies potential risks, and determines appropriate dosing and monitoring