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Generally, hypoxia itself can trigger angiogenesis by upregulating vascular endothelial growth factor (VEGF), hypoxia-inducible factor 1 (HIF1), T-cell intracellular antigen 1 (TIA1), eukaryotic translation initiation factor 2 (elF2), and thrombospondin (TSP1) [31]

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Peptide YY(336) inhibits gastric emptying and produces acute reductions in food intake in rhesus monkeys