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For Adrian, "the risk of compounding your own medicine far outweighs the risk of dying of a heart attack when you're in your 40s" due to unchecked obesity, he previously told Yahoo

Liu RY, Zhou JN, Hoogendijk WJG et al (2000) Decreased vasopressin gene expression in the biological clock of Alzheimer disease patients with and without depression

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Therefore, because neurotransmitter imbalance contributes to depressive behaviors in patients with depression as described above, the appropriate modulation of neurotransmitters in the brain is key to treating depression ( Figure 2 )