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This process leads to the generation of N-acetyl-p-benzoquinone imine (NAPQI) in amounts that depletes glutathione

GSTP1 is also involved in the detoxification process of benzo(a)pyrene (BaP), which excretes the conjugates of BaP metabolism and detoxification (52)

( c ) Energy expenditure recorded in metabolic cages (with ANCOVA using BW as covariate) and ( d ) corresponding ambulatory activity ( c , d : CON VEH n = 7, CON acyl-GIP n = 7, Gipr AP-KO n = 8 and Gipr AP-KO acyl GIP n = 8)

NAC improves phase 2 detoxification, and is a chelating agent for arsenic, cadmium, mercury, lead, excess copper, iron

Strikingly, oxidative stress also promoted HO-1 translocation to mitochondria, leading to mitochondrial iron overload and lipid reactive oxygen species (ROS) accumulation