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Appetite suppression and weight loss FIP cats frequently present with significant appetite loss, accelerating weight decline that is particularly dangerous in cats already under 2.5 kg

In the kindling model, chronic administration of subconvulsive doses of PTZ initiates the recurrence of seizures in a similar manner to the human epilepsy more than the acute models, where the seizure severity increases in a stepwise manner with each PTZ injection inducing severe generalized tonic-clonic seizures (Shimada and Yamagata 2018)