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One injection maintains elevated GH for a week

A.KutenaeeM

doi: 10.1016/j.it.2020.07.006

(2013) demonstrated that activation by ghrelin or the synthetic ghrelin agonist MK-0677 causes an increase in internalized dimers, yet no significant changes are observed when treated with the MC3R agonist [Nle 4 ,D-Phe 7 ]--MSH

These data suggest that ghrelin may aid in two ways: (1) by amplifying the remaining dopaminergic signaling through the D1R-GHSR1a dimer, and (2) by providing neuroprotective effects that may aid in slowing the progression of further dopaminergic degeneration, which may be the result of GHSR signaling alone