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For in vivo studies, a minimum of five mice per group was selected, which has been shown to be sufficient to detect biologically and statistically significant differences in similar experiments

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Regression analysis between fasting glucose and HbA 1C, carried out by pooling together diabetic patients and non-diabetic subjects (visits 1 and 3) values, resulted in the equation (see Supplementary Information, Section 7.1 and Figure S28 in File S1)

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