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SNO-Hb, S-nitrosohemoglobin Conflicts of interests: None declared

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Moderate intracellular GSH levels, however, are apparently not inhibitory for IL-2 production, since intracellular GSH depletion by cysteine starvation or by graded concentrations of DL-buthionine sulfoximine (BSO) had virtually no effect on IL-2-specific mRNA expression and the production of T cell growth factor (TCGF)

Any signs of methotrexate toxicityincluding mouth ulcers, unusual bruising, persistent sore throat, or shortness of breathrequire immediate medical attention