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Thus, peroxynitrite inhibits the enzymatic activity of PGI 2 synthase, thereby impairing PGI 2 -mediated vasodilation

Immunohistochemical staining and quantification of positive cells confirmed decreased numbers of Doublecortin-like kinase protein 1 (Dclk1) + tuft cells but stable numbers of serotonin containing (5-HT + ) enterochromaffin cell under inflammatory conditions in IL-10 -/- mice ( Figure 2C,D ), suggesting mechanisms specifically sustaining this cell population under inflammatory conditions

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