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Ligation of the T cell receptor (TCR) to MHC/antigen derived peptide complexes with concomitant interactions between CD28 on T cells and co-stimulators such as CD80 or CD86 on antigen presenting cells initiates signaling cascades that result in reprogramming of the cells metabolism (45, 46)

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However, several clinical situations, including insulin-resistant states, PCOS, gestational diabetes, and advanced maternal age, have been associated with reduced tissue myo-inositol concentrations or increased urinary loss, as documented in multiple studies between 2019 and 2024

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Thus, the rising geriatric population prone to diabetes across Asia Pacific would propel the demand for effective treatments such as GLP-1 analogues during the forecast period