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In other cases, the aetiology is not known, like for example in idiopathic pulmonary fibrosis (60), affecting mainly the elderly, or in systemic sclerosis, which presents with an autoimmune component and affects the skin as well as internal organs (61, 62)

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The median sample size across these studies was 23 patients (interquartile range (IQR): 6.338.5, average: 23, range: 342), with a median age of 36.9 years (IQR: 35.637)

To maintain oxidation equilibrium, HIF-1 activation under hypoxia suppresses mitochondrial respiration by inhibiting oxygen consumption and fatty acid oxidation via HIG2-mediated suppression of lipolysis

Understanding your genetic makeup, getting tested, and making lifestyle changes can optimize your health and reduce the risk of associated conditions