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TB-500 mechanism: Promotes systemic healing through actin regulation, stem cell mobilization, and anti-inflammatory cytokine signaling

Funding This research was supported by Consorcio Centro de Investigacin Biomdica en Red CIBER- de Diabetes y Enfermedades Metablicas Asociadas (CIBERDEM) (group [CB15/00071], leading group) and CIBER de Enfermedades Cardiovasculares (CIVERCV) [CB16/11/00257], Ministerio de Ciencia e Innovacin Instituto de Salud Carlos III (ISCIII), Spain

Consistent with this notion, under conditions of cysteine starvation, the GSH-catabolizing enzyme CHAC1 mobilizes cysteine to sustain mitochondrial Fe-S cluster biogenesis and respiratory function