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I could smoke a fairly large bowl of this without the woozies, but I preferred it in a small Group 5 due to the slow burn and the fact that it wore me out after two hours

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But in younger men with ED, cigarette smoking is very likely the cause

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Considering the specific safety concerns, contraindications (for example, bupropion is contraindicated in patients who have seizures) and comorbidities, the choice of agent is based largely on patient preference after discussion with a clinician [footnote 53]