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Extended continuous exposure to any signaling molecule can lead to receptor downregulation, where cells reduce sensitivity to maintain homeostasis

doi: 10.1073/pnas.1919893117 308 TrenkmannMBrockMGayREKollingCSpeichRMichelBAet al

[11] Hexarelins Potential Cardiac Protective Effects Another distinctive potential of hexarelin is its interaction with innate CD36 receptors

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