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In December 2024, the TRIUMPH-4 Phase 3 trial results were announced, showing that participants taking retatrutide 12 mg achieved an average weight loss of 71.8 pounds or 28.7% of body weight over 68 weeks

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However, rapid weight loss often comes with unwanted side effects: muscle loss (up to 20-60% of total weight lost) and sagging skin on areas like the arms, neck, or belly

Posey EA, He WL, Wu G