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Stopping GLP-1 medications typically leads to weight regain, with most people regaining 50-70% of lost weight within 12 months as appetite and metabolic adaptations return

However, Semaglutide is most effective when coupled with routine exercise and a healthy diet

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Most women get the recommended daily amount 2.4 micrograms (mcg) for most adults, 2.6 mcg for pregnant women, and 2.8 mcg for women who are breastfeeding in their diets