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The ability of mitochondria to rapidly adapt to stress, including stress imposed by antimetabolites such as 5FU, means that they have significant potential to dictate therapeutic responses 11

doi: 10.1016/j.brainresrev.2007.06.010

The model was first fitted to the training concentrations (37.5 and 25 M doxorubicin), and then used to simulate the test concentrations (50, 12.5 and 10 M doxorubicin) as a means of blind validation, showing good accordance between the experimental and in silico outputs for all concentrations of doxorubicin

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Your tirzepatide dose may be too high if your side effects feel intolerable