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Malate is the perfect complement to citrulline as Prez-Guisado et al points out Malateis capable of behaving as a metabolic shuttle between cytoplasm and mitochondria, enables bypassing of blockade of the oxidative pathway induced by ammonia, and hence limits accumulation of lactic acid by reorienting it toward pyruvate genesis and its aerobic utilization or neoglucogenesis

NAC (N-Acetylcysteine) is a precursor that helps your body make Glutathione, the bodys master antioxidant

This is because glutathione takes time to accumulate at the cellular level, where it begins neutralising free radicals, reducing oxidative stress, and gradually suppressing melanin synthesis

Qi et al., 2017

Because B12 and all other B vitamins are water-soluble, if you end up taking too much, they are easily eliminated in the urine