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Hyperactivity of entorhinal cortical and hippocampal circuits are also thought to underlie neurodegenerative disorders, such as AD and mild cognitive impairment (MCI) (268272)

The tricyclic antidepressant nortriptyline failed to improve symptoms in idiopathic gastroparesis [76]

High levels of oxidative stress may contribute to ALS onset, increasing motoneurons death, and heavy metals may be a cause for the increase of ROS

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