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In a phase 2 trial, once-weekly cagrilintide produced dose-dependent weight reductions in people with overweight or obesity, which is what moved the amylin pathway into serious combination development ( Lau et al., Lancet 2021 )

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Expression of GLP1-R was confirmed by RT-qPCR analysis of RNA from primary human chondrocytes from cartilage explants from 18 human OA patients (data not shown)

What GLP-1 Actually Does in Your Body GLP-1s are peptides, signaling molecules your body already makes

Conflict of interest: The authors declare no conflicts of interest