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This neurological overlap can: Increase sensitivity to other substances Make it harder to break addictive patterns Create psychological triggers that increase relapse risk Maintain the cycle of addictive behaviors Studies indicate that individuals who continue to smoke during recovery have higher relapse rates to their primary substance of abuse compared to those who quit smoking

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Conclusions In conclusion, this hypothesis improves our understanding of the critical role of TAMs, via CCL5 and VCAM-1 pathways, in E-cig promoted BC tumor development