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Potential chemotherapeutic effect of selenium for improved canceration of esophageal cancer
The medication carries a boxed warning for medullary thyroid carcinoma (MTC) risk, which originates from calcitonin-producing cells in the thyroid
Subsequently, cAMP phosphorylates protein kinase A (PKA), which in turn phosphorylates other regulatory proteins involved in airway smooth muscle spasm, regulation of intracellular calcium, and bronchodilation
Notably, Keap1 inactivation stabilizes Nrf2 and its target genes (such as key components of the SLC7A11/cysteine/glutathione (GSH) axis), promoting resistance to ferroptosis, which is crucial for inhibiting ferroptosis (Li J