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However, the onset of generic competition will likely significantly reduce the price, and this means the NHS can afford to treat more patients

Initially adaptive, this hyperfiltration response compensates for declining nephron mass but eventually exacerbates glomerular damage

Most participants adapted within weeks of reaching their maintenance dose

Dapagliflozin reduced the primary composite outcome (sustained 50% eGFR decline, ESKD, or death from renal or cardiovascular causes) by 39% compared to placebo [47]

It cant be used with adrenergic neuron blocking drugscommonly prescribed for high blood pressure, heart diseases, and migraines