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The low-MW fractions are pushed through the channels into the dermis, where they engage CD44 receptors on fibroblasts and contribute to volumetric hydration in deeper layers

The pace of removal of the adhesive tape is indirectly proportional to the quantity of skin removed from the patch, which is directly proportional to the adherence of the SC to the patch [279]

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doi: 10.1016/j.expneurol.2019.113061 191 SpenceRDHambyMEUmedaEItohNDuSWisdomAJet al

Scale back if pain increases beyond baseline, swelling returns, symptoms persist beyond 24 hours, or multiple consecutive sessions trigger increased symptoms