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HDAC6 Inhibition Mediated Protection from Hepatic Ischemia Reperfusion is Associated with Preserved Glutathione Levels 1 Surgery, University of Pennsylvania, Philadelphia, PA, 2 University of Pennsylvania, Philadelphia, PA, 3 Surgery, University of Pensylvania, Philadelphia, PA, 4 College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 5 Childrens Hospital of Philadelphia, Philadelphia, PA Meeting: 2022 American Transplant Congress Abstract number: 664 Keywords: Glutathione, Ischemia, Liver preservation Topic: Basic Science Basic Science 14 - Ischemia Reperfusion Session Information Session Name: Ischemia Reperfusion Session Type: Poster Abstract Date: Saturday, June 4, 2022 Session Time: 5:30pm-7:00pm Presentation Time: 5:30pm-7:00pm Location: Hynes Halls C & D *Purpose: Liver Ischemia reperfusion injury (IRI) and Acetaminophen (APAP) toxicity are important causes of acute liver failure in the United States, that lack effective therapy

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Morphologically and biochemically, ferroptosis is distinct from apoptosis, necrosis, and autophagy ( The cystine/glutamate antiporter system (System Xc )/GSH/GPX4 axis represents a central pathway in the regulation of ferroptosis

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