Under pathological conditions of TBI, the MCU protein on the inner mitochondrial membrane can transport a large amount of calcium ions into the mitochondria, disrupting the normal function of the mitochondria (Peng and Jou, 2010
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The -cells secrete GABA along with insulin and the GABA binds to GABA receptors on the neighboring islet alpha cells (-cells) and inhibits them from secreting glucagon (which would counteract insulin's effects)
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The risk is severe caloric restriction that drops below 800 to 1,000 calories per day, which triggers metabolic adaptation, muscle loss, nutrient deficiencies, and hormonal disruption
