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At the higher doses, results were very consistent: All participants lost at least 5% of their body weight Around 3 in 4 lost 15% or more With placebo, only around 1 in 4 lost 5% or more Phase 3 update (TRIUMPH-4, 68 weeks, topline results) In December 2025 , Eli Lilly shared early (topline) results from a larger phase 3 study (TRIUMPH-4)

Mathematical efficacy modeling supports this conclusion

A few medication tweaks can get symptoms under control so you can feel normal again

If you want Wegovy, Ozempic, or tirzepatide, you can upgrade (though at a higher cost)

Antibacterial activity and mechanism of berberine against Streptococcus agalactiae