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The estrogen-deficient state may disrupt this careful coordination of energy substrate uptake and utilization, impairing postprandial insulin-mediated suppression of adipose tissue lipolysis and leading to a chronic excess supply of circulating NEFA to the liver, eventually overwhelming its capacity for lipid removal to cause liver fat accumulation (86)

A 6-week safety period occurred after the 13-week treatment period

503B outsourcing facilities are subject to more FDA oversight than 503A pharmacies