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The BDNF Mechanism Explained The most well-documented mechanism of Semax is its ability to upregulate brain-derived neurotrophic factor (BDNF) in the hippocampus

J Strength Cond Res 34(5):14801495 Gonzalez AM, Spitz RW, Ghigiarelli JJ, Sell KM, Mangine GT (2018) Acute effect of citrulline malate supplementation on upper-body resistance exercise performance in recreationally resistance-trained men

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The vast majority of evidence comes from animal studies, which are promising but cannot be directly extrapolated to human outcomes