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Option 4: Telehealth prescription services Pathway: Sign up with online platform Complete medical questionnaire Video consultation with doctor Prescription issued if appropriate Peptides shipped from pharmacy Advantages: Convenient (all online) Legal and legitimate Cheaper than in-person clinics Quality assured Disadvantages: Still more expensive than research chemicals Limited to certain peptides Requires qualifying medical need Examples: Services like Maximus, Defy Medical, others for specific peptides

We extracted ten pre-specified variables: (1) comorbidity prevalence, (2) mean age, (3) gender ratio, (4) publication year, (5) EQ-5D version (3L/5L), (6) region (Europe, Americas, Asia, Oceania, Middle East), (7) sampling method, (8) administration mode, (9) survey venue, and (10) language

Participants with confirmed liver disease showed substantial reductions in liver fat content and, importantly, improvements in liver inflammation and fibrosis markers

While this flexibility can increase access and lower costs, it introduces variability that could impact efficacy and patient safety

5, Supplementary Fig