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No clear exit ramp GLP-1 medications function less like temporary diet aids and more like a treatment for a chronic condition

Within the body, it is located mostly in the skeletal and cardiac muscle tissue, liver, kidney, brain, and reproductive organs--all areas of high physiological activity

So when it comes to GLP-1s, GLP-1s are a tool

For neurodegenerative disease, pulmonary fibrosis, and autoimmune conditions, evidence remains preliminary with inconsistent outcome measures and small sample sizes

This limited de novo lipogenesis suggests that DKO cells rely on exogenous fatty acids for proliferation due to reduced ability to adequately synthesize their own fat despite maintaining higher or similar concentrations of malonyl-CoA (Figure 2C)