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Calcium, ischemia and excitotoxicity

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During the randomized treatment period, patients received a standard lifestyle instruction every 12 weeks on reduced-calorie diet (approximately 500 kcal/day deficit) and increased physical activity (recommended minimum of 150 min/week) that began with the first dose of ZEPBOUND or placebo and continued throughout the 72-week treatment period

Notably, researchers have documented that the peptide appears to upregulate NO production when it is deficient and downregulate it when excessive, suggesting a modulatory rather than simply stimulatory relationship