glp-1 muscle pain and its derived peptides mediate relief through direct TRPV1 inhibition without affecting thermoregulation Natural GLP-1 in Joint Fluid

Drouin J, Sun YL, Nemer M

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As semaglutide reduces weight, this risk should theoretically decrease, but the transition period, where rapid weight loss causes fluid shifts and muscle wasting, may temporarily increase risk before the long-term protective effects kick in

Moreover, dopamine contributes in the synthesis of noradrenaline and adrenaline as a precursor (130)