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For instance, a single-center study involving 200 type 2 diabetes patients, stratified by UACR categories (normal, micro-, and macroalbuminuria), found that the combined measurement of C16, C18:1, and C3 achieved an area under the receiver operating characteristic curve (AUC) of 0.89 for early DKD diagnosis, significantly outperforming UACR (AUC = 0.76) [147,148,149,150]

States agreed that partnering with CMS to develop and improve DSNP programs was important to program sustainability and high-quality care

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Overall, this evidence suggests that abnormally high or low levels of estradiol can both lead increased insulin resistance in the brain and peripheral tissues