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The long term administration (4 weeks) of aspirin and ibuprofen to rats increased mitochondrial number, altered liver mitochondria ultrastructure and increased the metabolic activity of the CYP450 enzymes 11

Wang, Y., Feng, X., Shen, B., Ma, J

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Free copper ions are toxic at high concentrations, but chelated within the GHK tripeptide, copper is delivered in a form that can serve as a co-factor for copper-dependent enzymes including lysyl oxidase (key for collagen cross-linking) and superoxide dismutase (key for antioxidant defence)

K.WenderN.HegermannJ.BrunnerB.et al (2010)