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Use low initial doses and increase the dose gradually [see Contraindications (4), Warnings and Precautions (5.3)]

Water itself has a hand in this

Common errors are failure to remove enough compromised tissue, and/or doing so in a way that injures the retained tissue

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An increase in their expression is associated with promoting the degradation of starch ( LOC107812614 related to starch synthase catalytic was downregulated, which could reduce starch synthesis