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Advanced cases may lead to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC) [2]

Some people report mild bloating or abdominal cramps during the first few days of use

Comparative structural analyses suggested that transition between the open and closed conformations in DHDPRs is determined by the binding of both substrate and nucleotide, given that only the DPA/NADPH-bound form of Pa DHDPR showed a closed conformation

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