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The authors report no other conflicts of interest in this work

Conditional recommendation for the intervention, low certainty Recommendation 10 Varenicline should be recommended to people who smoke and who have been assessed as clinically suitable for this medication

The reported decrease in cigarette consumption among participants in both treatment groups contributed to the observed decreases in FTND as number of cigarettes smoked per day is one out of the six items in the instrument

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Even people who smoke but do not inhale face an increased risk of developing mouth cancer