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Controversially, Nrf2 seems to have a dual effect in DKD

Arvanitakis, K., Koufakis, T., Kotsa, K

Erianin is used in a treatments, ranging from reducing diabetic complications and inhibiting pathological angiogenesis, to alleviating acute and chronic inflammation, as well as for other biological activities, including neuroprotection, anti-hepatic steatosis, anti-microbial effects (antiviral and antibacterial), anti-oxidation and reversal of drug resistance

Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood