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The questionnaire should cover personal and family medical history, current medications, contraindications, and risk factors for pancreatitis and thyroid conditions

Subgroup analyses highlighted enhanced benefits among older adults and diabetic patients, aligning with the hypothesis that the metabolic-inflammatory interface is the major driver of HFpEF

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We propose that the mechanism underlying sUA-induced inflammation is dependent on redox state changes and mitochondrial ROS production, in accordance with data demonstrating that high concentrations on uric acid may induce oxidative stress 94