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Altogether, the GWAS-PW results suggest pleiotropy of smoking-related and comorbid traits in our two novel ND-associated regions, but at the variant level, the rs2714700 and rs1862416 associations with ND are independent of the GSCAN-identified variants

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However, legality can vary based on local regulations regarding "smoking mixtures" and the specific individual herbs included in the blend

Traditional smoking introduces smoke, tar, and carbon monoxide into the mouth