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This research was supported by the National Research Foundation Singapore and the Singapore Ministry of Education under its Research Centres of Excellence initiative, NMRC/OFLCG/003/2018, Cancer ImmunoTherapy Imaging (CITI) Programme: Precision Immnue Cell Imaging for Precision Cancer Immunotherapy (H18/01/a0/018) and Joint NCIS and NUS Cancer Program Seed Funding Grants (R713-009272-733)
& Dayer, J
The peptide sequence incorporates critical modifications to native human amylin: an N-terminal lipidation with eicosanedioic acid conjugated through a gamma-glutamic acid linker, strategic proline substitutions to prevent fibril formation, and an amidated C-terminus to enhance receptor binding
In the TME, metabolic symbiosis is exemplified by the lactate shuttle, wherein tumor cells produce and export lactate as a result of aerobic glycolysis
