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All three GLP-1 analogs showed marked suppression of food intake and rapid weight loss effects immediately after administration (Fig
Current clinical evidence remains relatively weak, with only one study demonstrating that hydrogen therapy alone can improve UPDRS scores in PD (Yoritaka et al., 2013), while two additional studies suggest that hydrogen combined with other treatments may provide benefits for PD patients
J Struct Biol
2023;120:e2221713120
Specifically, exenatide treatment over 48 to 60 weeks increased tyrosine phosphorylation of insulin receptor substrate 1 (IRS-1) in neuronal-derived extracellular vesicles (exosomes), alongside activation of downstream signaling proteins such as total Akt and phosphorylated mTOR [61]
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