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Indeed, the fact that administration of phenformin can induce lactic acidosis, while metformin does not, suggests that these two biguanides act through different pathways (Garca Rubio et al., 2019)

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They accumulate

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Claims data can also be leveraged to understand the extent of off-label use of GLP-1s indicated for type 2 diabetes (e.g., Ozempic, Mounjaro) to assist in weight loss