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The results revealed a decrease in androgen receptor expression in both epithelial and stromal cells following 3 months of metformin treatment, while HOXA10 expression increased in stromal cells

This bidirectional modulation of the oral-gut axis provides a microecological basis for understanding how periodontal therapy reduces systemic low-grade inflammation

GPCRs play a crucial role in mediating cellular responses to a wide variety of extracellular signals, including neurotransmitter molecules and hormones, which activate G proteins